Clinical and Laboratory Findings of the First Imported Case of Middle East Respiratory Syndrome Coronavirus to the United States
Identifieur interne : 001E57 ( Main/Exploration ); précédent : 001E56; suivant : 001E58Clinical and Laboratory Findings of the First Imported Case of Middle East Respiratory Syndrome Coronavirus to the United States
Auteurs : Minal Kapoor [Allemagne] ; Kimberly Pringle [États-Unis] ; Alan Kumar [Allemagne] ; Stephanie Dearth [États-Unis] ; LIXIA LIU [États-Unis] ; Judith Lovchik [États-Unis] ; Omar Perez [États-Unis] ; Pam Pontones [États-Unis] ; Shawn Richards [États-Unis] ; Jaime Yeadon-Fagbohun [États-Unis] ; Lucy Breakwell [États-Unis] ; Nora Chea [États-Unis] ; Nicole J. Cohen [États-Unis] ; Eileen Schneider [États-Unis] ; Dean Erdman [États-Unis] ; Lia Haynes [États-Unis] ; Mark Pallansch [États-Unis] ; YING TAO [États-Unis] ; SUXIANG TONG [États-Unis] ; Susan Gerber [États-Unis] ; David Swerdlow [États-Unis] ; Daniel R. Feikin [États-Unis]Source :
- Clinical infectious diseases [ 1058-4838 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Infections à coronavirus.
- diagnostic : Infections à coronavirus.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Infections à coronavirus.
- Pascal (Inist)
- Wicri :
- geographic : Arabie saoudite, États-Unis.
English descriptors
- KwdEn :
- Aged, Clinical biology, Coronavirus, Coronavirus Infections (diagnosis), Coronavirus Infections (pathology), Coronavirus Infections (virology), Humans, Imported disease, Infection, Male, Middle East Respiratory Syndrome Coronavirus (isolation & purification), Middle East respiratory syndrome, Saudi Arabia, Symptomatology, Travel, United States.
- MESH :
- geographic : Saudi Arabia, United States.
- diagnosis : Coronavirus Infections.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- pathology : Coronavirus Infections.
- virology : Coronavirus Infections.
- Aged, Humans, Male, Travel.
Abstract
Background. The Middle East respiratory syndrome coronavirus (MERS-CoV) was discovered September 2012 in the Kingdom of Saudi Arabia (KSA). The first US case of MERS-CoV was confirmed on 2 May 2014. Methods. We summarize the clinical symptoms and signs, laboratory and radiologic findings, and MERS-CoV-specific tests. Results. The patient is a 65-year-old physician who worked in a hospital in KSA where MERS-CoV patients were treated. His illness onset included malaise, myalgias, and low-grade fever. He flew to the United States on day of illness (DOI) 7. His first respiratory symptom, a dry cough, developed on DOI 10. On DOI 11, he presented to an Indiana hospital as dyspneic, hypoxic, and with a right lower lobe infiltrate on chest radiography. On DOI 12, his serum tested positive by real-time reverse transcription polymerase chain reaction (rRT-PCR) for MERS-CoV and showed high MERS-CoV antibody titers, whereas his nasopharyngeal swab was rRT-PCR negative. Expectorated sputum was rRT-PCR positive the following day, with a high viral load (5.31 × 106 copies/mL). He was treated with antibiotics, intravenous immunoglobulin, and oxygen by nasal cannula. He was discharged on DOI 22. The genome sequence was similar (>99%) to other known MERS-CoV sequences, clustering with those from KSA from June to July 2013. Conclusions. This patient had a prolonged nonspecific prodromal illness before developing respiratory symptoms. Both sera and sputum were rRT-PCR positive when nasopharyngeal specimens were negative. US clinicians must be vigilant for MERS-CoV in patients with febrile and/or respiratory illness with recent travel to the Arabian Peninsula, especially among healthcare workers.
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Le document en format XML
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Health</s1><s2>Indianapolis, Indiana</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Yeadon Fagbohun, Jaime" sort="Yeadon Fagbohun, Jaime" uniqKey="Yeadon Fagbohun J" first="Jaime" last="Yeadon-Fagbohun">Jaime Yeadon-Fagbohun</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Indiana State Department of Health</s1><s2>Indianapolis, Indiana</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Breakwell, Lucy" sort="Breakwell, Lucy" uniqKey="Breakwell L" first="Lucy" last="Breakwell">Lucy Breakwell</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Epidemic Intelligence Service, Division of Scientific Education and Professional Development, Centers for Disease Control and Prevention</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Chea, Nora" sort="Chea, Nora" uniqKey="Chea N" first="Nora" last="Chea">Nora Chea</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Epidemic Intelligence Service, Division of Scientific Education and Professional Development, Centers for Disease Control and Prevention</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Cohen, Nicole J" sort="Cohen, Nicole J" uniqKey="Cohen N" first="Nicole J." last="Cohen">Nicole J. Cohen</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Division of Global Migration and Quarantine, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Schneider, Eileen" sort="Schneider, Eileen" uniqKey="Schneider E" first="Eileen" last="Schneider">Eileen Schneider</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Division of Viral Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Erdman, Dean" sort="Erdman, Dean" uniqKey="Erdman D" first="Dean" last="Erdman">Dean Erdman</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Division of Viral Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Haynes, Lia" sort="Haynes, Lia" uniqKey="Haynes L" first="Lia" last="Haynes">Lia Haynes</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Division of Viral Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Pallansch, Mark" sort="Pallansch, Mark" uniqKey="Pallansch M" first="Mark" last="Pallansch">Mark Pallansch</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Division of Viral Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Ying Tao" sort="Ying Tao" uniqKey="Ying Tao" last="Ying Tao">YING TAO</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Division of Viral Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Suxiang Tong" sort="Suxiang Tong" uniqKey="Suxiang Tong" last="Suxiang Tong">SUXIANG TONG</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Division of Viral Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Gerber, Susan" sort="Gerber, Susan" uniqKey="Gerber S" first="Susan" last="Gerber">Susan Gerber</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Division of Viral Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Swerdlow, David" sort="Swerdlow, David" uniqKey="Swerdlow D" first="David" last="Swerdlow">David Swerdlow</name><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>21 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Feikin, Daniel R" sort="Feikin, Daniel R" uniqKey="Feikin D" first="Daniel R." last="Feikin">Daniel R. Feikin</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Division of Viral Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Clinical infectious diseases</title><title level="j" type="abbreviated">Clin. infect. dis.</title><idno type="ISSN">1058-4838</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Clinical infectious diseases</title><title level="j" type="abbreviated">Clin. infect. dis.</title><idno type="ISSN">1058-4838</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Clinical biology</term><term>Coronavirus</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (pathology)</term><term>Coronavirus Infections (virology)</term><term>Humans</term><term>Imported disease</term><term>Infection</term><term>Male</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>Middle East respiratory syndrome</term><term>Saudi Arabia</term><term>Symptomatology</term><term>Travel</term><term>United States</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Arabie saoudite</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Humains</term><term>Infections à coronavirus (anatomopathologie)</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (virologie)</term><term>Mâle</term><term>Sujet âgé</term><term>Voyage</term><term>États-Unis d'Amérique</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Saudi Arabia</term><term>United States</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Humans</term><term>Male</term><term>Travel</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Arabie saoudite</term><term>Humains</term><term>Maladie d'importation</term><term>Mâle</term><term>Sujet âgé</term><term>Symptomatologie</term><term>Biologie clinique</term><term>Etats-Unis</term><term>Coronavirus</term><term>Infection</term><term>Syndrome respiratoire du Moyen-Orient</term><term>Voyage</term><term>États-Unis d'Amérique</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Arabie saoudite</term><term>États-Unis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background. The Middle East respiratory syndrome coronavirus (MERS-CoV) was discovered September 2012 in the Kingdom of Saudi Arabia (KSA). The first US case of MERS-CoV was confirmed on 2 May 2014. Methods. We summarize the clinical symptoms and signs, laboratory and radiologic findings, and MERS-CoV-specific tests. Results. The patient is a 65-year-old physician who worked in a hospital in KSA where MERS-CoV patients were treated. His illness onset included malaise, myalgias, and low-grade fever. He flew to the United States on day of illness (DOI) 7. His first respiratory symptom, a dry cough, developed on DOI 10. On DOI 11, he presented to an Indiana hospital as dyspneic, hypoxic, and with a right lower lobe infiltrate on chest radiography. On DOI 12, his serum tested positive by real-time reverse transcription polymerase chain reaction (rRT-PCR) for MERS-CoV and showed high MERS-CoV antibody titers, whereas his nasopharyngeal swab was rRT-PCR negative. Expectorated sputum was rRT-PCR positive the following day, with a high viral load (5.31 × 10<sup>6</sup> copies/mL). He was treated with antibiotics, intravenous immunoglobulin, and oxygen by nasal cannula. He was discharged on DOI 22. The genome sequence was similar (>99%) to other known MERS-CoV sequences, clustering with those from KSA from June to July 2013. Conclusions. This patient had a prolonged nonspecific prodromal illness before developing respiratory symptoms. Both sera and sputum were rRT-PCR positive when nasopharyngeal specimens were negative. US clinicians must be vigilant for MERS-CoV in patients with febrile and/or respiratory illness with recent travel to the Arabian Peninsula, especially among healthcare workers.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Indiana</li></region></list><tree><country name="Allemagne"><noRegion><name sortKey="Kapoor, Minal" sort="Kapoor, Minal" uniqKey="Kapoor M" first="Minal" last="Kapoor">Minal Kapoor</name></noRegion><name sortKey="Kumar, Alan" sort="Kumar, Alan" uniqKey="Kumar A" first="Alan" last="Kumar">Alan Kumar</name></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Pringle, Kimberly" sort="Pringle, Kimberly" uniqKey="Pringle K" first="Kimberly" last="Pringle">Kimberly Pringle</name></region><name sortKey="Breakwell, Lucy" sort="Breakwell, Lucy" uniqKey="Breakwell L" first="Lucy" last="Breakwell">Lucy Breakwell</name><name sortKey="Chea, Nora" sort="Chea, Nora" uniqKey="Chea N" first="Nora" last="Chea">Nora Chea</name><name sortKey="Cohen, Nicole J" sort="Cohen, Nicole J" uniqKey="Cohen N" first="Nicole J." last="Cohen">Nicole J. Cohen</name><name sortKey="Dearth, Stephanie" sort="Dearth, Stephanie" uniqKey="Dearth S" first="Stephanie" last="Dearth">Stephanie Dearth</name><name sortKey="Erdman, Dean" sort="Erdman, Dean" uniqKey="Erdman D" first="Dean" last="Erdman">Dean Erdman</name><name sortKey="Feikin, Daniel R" sort="Feikin, Daniel R" uniqKey="Feikin D" first="Daniel R." last="Feikin">Daniel R. Feikin</name><name sortKey="Gerber, Susan" sort="Gerber, Susan" uniqKey="Gerber S" first="Susan" last="Gerber">Susan Gerber</name><name sortKey="Haynes, Lia" sort="Haynes, Lia" uniqKey="Haynes L" first="Lia" last="Haynes">Lia Haynes</name><name sortKey="Lixia Liu" sort="Lixia Liu" uniqKey="Lixia Liu" last="Lixia Liu">LIXIA LIU</name><name sortKey="Lovchik, Judith" sort="Lovchik, Judith" uniqKey="Lovchik J" first="Judith" last="Lovchik">Judith Lovchik</name><name sortKey="Pallansch, Mark" sort="Pallansch, Mark" uniqKey="Pallansch M" first="Mark" last="Pallansch">Mark Pallansch</name><name sortKey="Perez, Omar" sort="Perez, Omar" uniqKey="Perez O" first="Omar" last="Perez">Omar Perez</name><name sortKey="Pontones, Pam" sort="Pontones, Pam" uniqKey="Pontones P" first="Pam" last="Pontones">Pam Pontones</name><name sortKey="Richards, Shawn" sort="Richards, Shawn" uniqKey="Richards S" first="Shawn" last="Richards">Shawn Richards</name><name sortKey="Schneider, Eileen" sort="Schneider, Eileen" uniqKey="Schneider E" first="Eileen" last="Schneider">Eileen Schneider</name><name sortKey="Suxiang Tong" sort="Suxiang Tong" uniqKey="Suxiang Tong" last="Suxiang Tong">SUXIANG TONG</name><name sortKey="Swerdlow, David" sort="Swerdlow, David" uniqKey="Swerdlow D" first="David" last="Swerdlow">David Swerdlow</name><name sortKey="Yeadon Fagbohun, Jaime" sort="Yeadon Fagbohun, Jaime" uniqKey="Yeadon Fagbohun J" first="Jaime" last="Yeadon-Fagbohun">Jaime Yeadon-Fagbohun</name><name sortKey="Ying Tao" sort="Ying Tao" uniqKey="Ying Tao" last="Ying Tao">YING TAO</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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